Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module
Sofía Zdral, Simone Giulio Bordignon, Axel Meyer…·Joost M. Woltering
This study identifies the evolutionary origin of the dorsoventral axis in paired appendages by showing Lmx1b's ancestral role in midline fins and its repurposing through novel regulatory inputs.