Sofía Zdral

This study identifies the evolutionary origin of the dorsoventral axis in paired appendages by showing Lmx1b's ancestral role in midline fins and its repurposing through novel regulatory inputs.

The paper identifies ancestral dorsal-ventral patterning mechanisms in fish fins and shows evolutionary innovations in their regulation.

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

This study identifies two mammalian-specific enhancers upstream of the HoxC gene cluster that regulate Hoxc gene expression in ectodermal organs like hair and nails.