Tobias Sargeant

AlphaGenome predicts functional genomic measurements from DNA sequences with high resolution and accuracy across multiple modalities, outperforming existing methods in variant effect prediction.

This study uses cellular barcoding and agent-based modeling to reveal clonal fate patterns in hematopoiesis, showing that stem and progenitor cells are often less multipotent than previously thought.

SuperFreq detects mutations and tracks clones in cancer samples without requiring matched normal samples, achieving high accuracy in identifying clones and mutations.

SIS-seq links gene expression with cell fate by analyzing clonal progeny, identifying early gene signatures of dendritic cell subset development.

This study analyzes DNA and RNA sequencing data from follicular lymphoma patients to identify mutations and transcriptional changes during transformation to diffuse large B cell lymphoma.