Bradley McIntosh Broom

PCA-Plus enhances principal component analysis to better detect, visualize, and quantify batch effects and group differences in multi-omic data.

OmicPioneer-sc provides an interactive visualization tool for single-cell sequencing data, integrating dimensionality reduction, heat maps, and pathway modules to aid in cell-type annotation and multi-omic analysis.

The paper introduces a method to construct gene-specific methylation profiles for integrative methylation-expression analysis in cancer, showing improved explanation of expression variability and identification of methylation differences across cancer subtypes.