Author

Isaac Meza‐Padilla

University of WaterlooORCID 0000-0002-0934-0920Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jozef I. NissimoviD· 4 shared Andrew C. DoxeyiD· 1 shared Brendan J. McConkeyiD· 1 shared Kirsten M. MülleriD· 1 shared Sarit AvraniiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 5 mutual co-author links

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4 shared papersMicrobiology

Jozef I. NissimovORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 13, 2026

Gas-vacuolate Microcystis evolves cyanophage resistance under low nitrogen conditions

Isaac Meza‐Padilla, Jozef I. Nissimov

The paper shows gas-vacuolate Microcystis aeruginosa develops virus resistance under low nitrogen, with a mutation in a nitrogen transporter linked to this adaptation.

DOI 10.64898/2026.07.12.738045

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologyThe ISME JournalPeer-reviewedJan 1, 2026

A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere

Isaac Meza‐Padilla, Sarit Avrani, Kirsten M. Müller, Jozef I. Nissimov

The paper reannotates the genome of the jumbo cyanophage PhiMa05, revealing it encodes multiple ribosomal proteins and related genes, suggesting horizontal gene transfer to host bacteria.

3 citationstop 2%

bacteria (other)experimental assay

𝕏 PostBluesky

BioinformaticsComputational and Structural Biotechnology JournalPeer-reviewedJan 1, 2025

AlphaFold 3 proteomic modelling reveals multiple photosystem structural homologs in freshwater cyanophages

Isaac Meza‐Padilla, Andrew C. Doxey, Jozef I. Nissimov

The paper uses AlphaFold 3 and DALI to predict structures and functions of viral genes in cyanophages, identifying 28 new structural homologs including cyanobacteriochrome.

3 citations

protein structuredeep learning

𝕏 PostBluesky

MicrobiologyVirus EvolutionPeer-reviewedSep 24, 2024

Structural models predict a significantly higher binding affinity between the NblA protein of cyanophage Ma-LMM01 and the phycocyanin of Microcystis aeruginosa NIES-298 compared to the host homolog

Isaac Meza‐Padilla, Brendan J. McConkey, Jozef I. Nissimov

The paper uses structural modeling to show that the viral NblA protein from cyanophage Ma-LMM01 binds more strongly to host phycocyanin than the host's own NblA.

7 citations

virusbacteria (other)

𝕏 PostBluesky