GeneticsbioRxivPreprint
Cell division can accelerate the loss of a heteroplasmic mitochondrial DNA mutation in a mouse model of mitochondrial disease
Tianhong Su, Tiago M. Bernardino Gomes, Anna L M Smith…·Laura C. Greaves
The paper shows that cell division reduces mtDNA mutation load in mitotic tissues of a mouse model, while post-mitotic tissues maintain stable mutation levels.
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