James Bruce Stewart

Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.

This study shows that errors in mitochondrial translation cause cellular stress and metabolic changes linked to disease and aging, independent of oxidative phosphorylation.

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

Cell division can accelerate the loss of a heteroplasmic mitochondrial DNA mutation in a mouse model of mitochondrial disease

The paper shows that cell division reduces mtDNA mutation load in mitotic tissues of a mouse model, while post-mitotic tissues maintain stable mutation levels.

Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis

This study shows that overactive mitochondrial DNA replication causes neonatal heart failure through ferroptosis by disrupting cardiac maturation and oxidative metabolism.

Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function

The paper analyzes 184 octocoral mitochondrial genomes to study mt-mutS evolution and function, finding evidence for its role in DNA repair and its impact on sequence evolution rates.