Laura C. Greaves

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

The Transcription Factor Sob Maintains Intestinal Stem Cell Homeostasis to Delay Ageing

This study identifies Sob as a transcription factor that maintains intestinal stem cell homeostasis and delays ageing in Drosophila by regulating proliferation and differentiation.

Loss of HMGCS2-mediated intestinal stem cell ketogenesis is a metabolic barrier to mucosal healing in Ulcerative colitis

The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.

Cell division can accelerate the loss of a heteroplasmic mitochondrial DNA mutation in a mouse model of mitochondrial disease

The paper shows that cell division reduces mtDNA mutation load in mitotic tissues of a mouse model, while post-mitotic tissues maintain stable mutation levels.