Macrophage Phagocytic Impairment is associated with Dysbiosis of the Respiratory Microbiome in Frail older adults
Kylie B. R. Belchamber, Kay Por Yip, Onn Shaun Thein, Frances Susanna Grudzinska, S. Patel, Elizabeth Sapey, Thomas Jackson, Dhruv Parekh, Michael J. Cox, Aaron Scott
This study finds that frail older adults have impaired macrophage phagocytosis and a less diverse respiratory microbiome, which may be linked to PPARγ pathway dysfunction.
bioRxiv · Feb 11, 2026 · PreprintImmunology