Vardges Tserunyan

The paper applies information theory to analyze CAR-4-1BB-mediated NFκB activation in cell signaling, finding that fold change in nuclear NFκB concentration has higher channel capacity than absolute response.

The paper models 4-1BB-induced NFκB signaling in CAR cells to identify design improvements for enhanced antigen response.

The paper uses mathematical modeling to show that CD28-bearing CARs lead to faster and more consistent T cell responses under variability, with LCK activity influencing response times.

The paper shows microtubules stabilize actomyosin attachments to adherens junctions during Drosophila mesoderm invagination, facilitating intercellular force transmission.