Hyeongmin Seo

Enabling supratheoretical isopropanol yields from carbon-negative glucose fermentations with Clostridium acetobutylicum-Clostridium ljungdahlii cocultures

This study shows that high cell density cocultures of genetically modified Clostridium acetobutylicum and wild-type Clostridium ljungdahlii enable supratheoretical isopropanol yields from glucose fermentation.

Butyrate as a growth factor of Clostridium acetobutylicum

This study shows that butyrate stimulates growth, health, and sporulation in Clostridium acetobutylicum and acts as a growth factor, potentially modulating microbial population dynamics.

Engineering a Synthetic Escherichia coli Coculture for Compartmentalized de novo Biosynthesis of Isobutyl Butyrate from Mixed Sugars

This paper engineers a synthetic E. coli coculture to compartmentalize sugar utilization and ester biosynthesis pathways, achieving 31-fold higher isobutyl butyrate production than monocultures.

Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters

This study demonstrates a modular design approach to selectively produce isoamyl acetate in microbes, achieving high titer, yield, and selectivity through proteome reallocation.

Repurposing chloramphenicol acetyltransferase for a robust and efficient designer ester biosynthesis platform

The paper repurposes chloramphenicol acetyltransferases to create efficient ester biosynthesis enzymes, demonstrating high titer and conversion in microbial hosts.

Single mutation at a highly conserved region of chloramphenicol acetyltransferase enables thermophilic isobutyl acetate production directly from cellulose by Clostridium thermocellum

This study engineers a thermostable chloramphenicol acetyltransferase to enable isobutyl acetate production from cellulose by Clostridium thermocellum at elevated temperatures.