ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis.
Simone Bini, Valeria Pecce, Alessandra Pinzon Grimaldos, Alessia Di Costanzo, Ilenia Minicocci, Stella Covino, Daniele Tramontano, Silvia Piconese, Laura D’Erasmo, Marcello Arca
This study identifies a direct interaction between ANGPTL3 and PCSK9, showing they form a complex that regulates intracellular lipid homeostasis by modulating LDL uptake, degradation, and metabolism.
bioRxiv · Jan 5, 2025 · PreprintCell Biology