Author

Marcello Arca

Sapienza University of RomeORCID 0000-0003-3786-0883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessia Di CostanzoiD· 2 shared Ilenia MinicocciiD· 2 shared Laura D’ErasmoiD· 2 shared Alessandra Pinzon Grimaldos· 1 shared Daniele TramontanoiD· 1 shared Eleonora PoggiogalleiD· 1 shared Emmi TikkaneniD· 1 shared Jenni HällforsiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Alessia Di CostanzoORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 5, 2025

ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis.

Simone Bini, Valeria Pecce, Alessandra Pinzon Grimaldos…·Marcello Arca

This study identifies a direct interaction between ANGPTL3 and PCSK9, showing they form a complex that regulates intracellular lipid homeostasis by modulating LDL uptake, degradation, and metabolism.

DOI 10.1101/2025.01.05.631413

humanproteomics

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GeneticsArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewedFeb 28, 2019

Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state

Emmi Tikkanen, Ilenia Minicocci, Jenni Hällfors…·Marcello Arca

This study examines the metabolic effects of ANGPTL3 deficiency in fasting and postprandial states, finding reduced lipoprotein cholesterol and increased ketone bodies in carriers.

41 citations

humanmetabolomics

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