NeuroscienceNature MethodsPeer-reviewed
CaBLAM! A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase
Gerard G. Lambert, Emmanuel L. Crespo, Jeremy Murphy…·Nathan C. Shaner
This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.