Assaf A. Gilad

This paper uses machine learning to design Gd-binding peptides with improved relaxivity and specificity for MRI contrast agents.

The paper develops a gene circuit that uses light and magnetic stimuli to control gene expression in mammalian cells.

This paper describes a biocatalytic method to synthesize 5-MDHT, a CEST MRI probe, and validates its effectiveness using CEST-MRI.

This study shows that activating the EPG protein with magnetic fields increases intracellular manganese uptake, suggesting MEMRI can monitor EPG's neuromodulatory effects.

The paper develops a new RF pulse shape for CEST MRI using gradient ascent optimization, showing improved contrast in phantoms and live mice compared to Gaussian and Fermi pulses.

This paper introduces a magnetogenetic stimulation method in rats that modulates neural circuits and measures brain activity via MRI, showing increased signal fluctuations and functional connectivity.

The paper identifies a conserved phenylalanine motif in Teleost fish that may enhance electromagnetic perception, with functional variants linked to freshwater environments.

This paper introduces a method to reconstitute split proteins using magnetic stimulation, demonstrating it with NanoLuc, APEX2, and Herpes Simplex Virus Type-1 Thymidine Kinase.

The paper develops a synthetic biosensor for CEST MRI using in-silico optimized peptides, showing comparable contrast to existing agents.

The paper develops a bioluminescent genetically encoded glutamate indicator for in vivo neuronal activity monitoring without requiring external light sources.

The paper identifies a three-phenylalanine motif critical for magnetoreception in the EPG protein from Kryptopterus vitreolus when expressed in mammalian cells.

This study demonstrates that magnetogenetics using the EPG gene in inhibitory interneurons can reduce seizure frequency and delay onset in a rat epilepsy model.

The paper introduces POET, a genetic programming tool for protein optimization, demonstrating its ability to generate proteins with significantly improved MRI contrast and novel functions.

This study shows that rTMS and the EPG gene improve mobility, reduce anxiety, and enhance neuroplasticity after nerve injury in rats.

This paper characterizes the EPG protein's cellular location, orientation, and dynamics in response to magnetic stimulation, providing insights into magnetoreception mechanisms and magnetogenetics.