Emmanuel L. Crespo

This paper introduces a modular platform called Interluminescence that uses bioluminescent light to control synaptic transmission by activating optogenetic ion channels in postsynaptic neurons.

The paper introduces BLADe, a platform that converts intracellular activity into photoreceptor activation using bioluminescent sensors and actuators, demonstrating its use in neurons for activity-dependent gene expression and neural dynamics control.

This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.

This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.

The paper investigates presymptomatic manipulation of cortical neuron activity in HD mice to restore E/I balance and slow disease progression.

This study evaluates factors affecting luminopsin efficacy and identifies strategies to improve their function through molecular evolution.

The paper develops a bioluminescent genetically encoded glutamate indicator for in vivo neuronal activity monitoring without requiring external light sources.

The paper introduces a new bioluminescent optogenetic molecule (LMO7) that enhances chemogenetic activation efficacy compared to existing variants, showing improved neuronal activity modulation and behavioral control.

The paper introduces a method to control synaptically connected neurons using bioluminescent light, validated in cultured neurons and mice.

The paper shows that hyperexcitation of specific neocortical neurons during early development causes long-term behavioral and circuit deficits in adulthood.