Joshua S. Schiffman

Ordered lineage recording in lung cancer xenografts shows pre-transplant glycolytic and lineage-heritable expression states predict metastatic colonization, while ENO1 alone predicts onward spread.

This paper develops SMART-PTA for single-cell whole-genome and transcriptome sequencing, revealing clonal evolution in aged human esophageal tissue over 70 years.

This paper introduces MRD-EDGE, a machine learning platform for ultrasensitive ctDNA detection in plasma WGS, showing improved sensitivity and broader applicability for MRD monitoring.