Tamara Prieto

This paper introduces D&D-seq, a single-cell method to map DNA:Protein interactions with high specificity and resolution, and applies it to study TF binding in human cells.

This paper develops SMART-PTA for single-cell whole-genome and transcriptome sequencing, revealing clonal evolution in aged human esophageal tissue over 70 years.

This paper introduces ppmSeq, a sequencing technology that improves accuracy and efficiency in detecting SNVs by sequencing both DNA strands, showing superior performance in clinical applications like ctDNA detection.

The paper uses single-cell sequencing to uncover hidden genetic diversity in pediatric ALL that is not detected by bulk sequencing, identifying treatment-resistant clones and their associated mutations.

This study evaluates somatic variant calling methods on multiregional tumor data, finding that multisample approaches do not always outperform single-sample methods, with Mutect2 in multisample mode performing best under challenging conditions.

This study compares six single-cell whole-genome amplification methods using human cells, finding that REPLIg performs best in DNA yield and uniformity while Ampli1 shows fewer technical artifacts.