Targeting C2 reduces ischemia-reperfusion injury-induced complement activation in preclinical human models
Elisabeth de Zeeuw, Laura M. Tool, Daniëlle Krijgsman, Eline Haspeslagh, Inge Van de Walle, Jolien Delaere, C. Erik Hack, Jeanette H.W. Leusen, Kevin Budding, Linda Gijzen
This study shows that targeting C2 reduces complement activation in human kidney ischemia-reperfusion injury models using 2D and 3D in vitro systems.
bioRxiv · Oct 27, 2025 · PreprintCell Biology