Author

Ashim Nandi

University of Southern CaliforniaORCID 0000-0002-1090-7664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aoxuan Zhang· 1 shared Arieh WarsheliD· 1 shared Dangliang LiuiD· 1 shared Qijia WeiiD· 1 shared Suwei DongiD· 1 shared Wen Jun XieiD· 1 shared Xiaoya WangiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Aoxuan Zhang

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1 paper

Recent·Most cited

Enhancing Luciferase Activity and Stability through Generative Modeling of Natural Enzyme Sequences

Wen Jun Xie, Dangliang Liu, Xiaoya Wang, Aoxuan Zhang, Qijia Wei, Ashim Nandi, Suwei Dong, Arieh Warshel

This study uses generative modeling and biochemistry to improve luciferase activity and stability by engineering its active center and scaffold, achieving a 50% success rate for single mutants.

Proceedings of the National Academy of Sciences · Nov 20, 2023Peer-reviewedBioinformatics