BioinformaticsProceedings of the National Academy of SciencesPeer-reviewed
Enhancing Luciferase Activity and Stability through Generative Modeling of Natural Enzyme Sequences
Wen Jun Xie, Dangliang Liu, Xiaoya Wang…·Arieh Warshel
This study uses generative modeling and biochemistry to improve luciferase activity and stability by engineering its active center and scaffold, achieving a 50% success rate for single mutants.
27 citations