Wen Jun Xie

This study uses generative modeling and biochemistry to improve luciferase activity and stability by engineering its active center and scaffold, achieving a 50% success rate for single mutants.

This paper reviews how generative AI can be used to analyze enzyme sequences, predict mutation effects, and improve enzyme engineering by uncovering functional patterns and evolutionary relationships.

This study uses an information-theoretic model to infer the mechanism of chromatin domain formation from epigenetic data, revealing distinct domain types and their formation dynamics.