Author

Nolan P Jacob

University of North Carolina at Chapel HillORCID 0000-0002-1115-9223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Huong T. KratochviliD· 2 shared Fábio Pereira GomesiD· 1 shared Gisselle Prida Ajo· 1 shared Heedeok HongiD· 1 shared Jiayi LiiD· 1 shared John R. YatesiD· 1 shared Marco MraviciD· 1 shared Masy DomecilloiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Huong T. KratochvilORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 15, 2026

De novo design of transmembrane accessory subunits for fold stabilization and expansion

Sebastian Jojoa-Cruz, Saba Kanwal, Nolan P Jacob…·Marco Mravic

This paper designs synthetic transmembrane subunits to stabilize and expand membrane proteins, demonstrating their utility in structural biology and disease treatment.

DOI 10.64898/2026.05.14.725059

protein structuredeep learning

𝕏 PostBluesky

BiophysicsbioRxivPreprintApr 14, 2026

Engineered Channel Asymmetry Extends Hydrogen-Bonding Networks for Proton Conduction

Nolan P Jacob, Vincent Silverman, Gisselle Prida Ajo, Huong T. Kratochvil

This paper engineers proton-conductive channels by introducing asymmetry in polar sidechains to enhance hydrogen-bonding network connectivity and proton transport efficiency.

DOI 10.64898/2026.04.11.717926

experimental assayprotein folding & dynamics

𝕏 PostBluesky