Masy Domecillo

This paper introduces AlphaProtein Novo, a machine-learning pipeline for de novo enzyme design that outperforms natural sequence mining in creating enzymes for new-to-nature chemistry and substrates.

This study adapts Edman degradation and amino acid recognition to expansion microscopy gels to demonstrate in situ protein sequencing principles using synthetic constructs.

This paper designs synthetic transmembrane subunits to stabilize and expand membrane proteins, demonstrating their utility in structural biology and disease treatment.

The paper determines the structure of MreC-MreD complex and shows how MreD controls MreC conformation, essential for bacterial cell shape and antibiotic targeting.