Molecular Rewiring in TNNT2-Linked Hypertrophic Cardiomyopathy hiPSC-Derived Cardiomyocytes upon Metabolic Maturation
Homa Hamledari, Farah Jayousi, Sanam Shafaattalab, Saif Dababneh, Ramon I. Klein Geltink, Philipp F. Lange, Maksymilian Prondzynski, Glen F. Tibbits, Sheila S. Teves
This study investigates how metabolic maturation affects molecular and metabolic states in hiPSC-derived cardiomyocytes with TNNT2-linked hypertrophic cardiomyopathy, revealing variant-specific disruptions in metabolic pathways and gene regulation.
bioRxiv · Sep 14, 2025 · PreprintMolecular Biology