Pierre Nicolas

Inference on paths of yeast transcription pre-initiation complex assembly by model-based analysis of altered occupancy profiles

This study develops a quantitative framework to infer PIC assembly paths in yeast using ChIP-seq data from Mediator mutants, revealing gene-specific and pathway-dependent variations.

CRISPR interference functional genomics of coding and non-coding determinants of Bacillus subtilis biofilms

This study uses CRISPRi to identify gene functions in two Bacillus subtilis biofilm types, revealing shared and distinct genetic pathways for their formation.

ModuloStat: An Internet of Things' Path to Continuous Cultures in Mini-Bioreactors

The paper introduces ModuloStat, an open-source framework for continuous microbial culture in mini-bioreactors, demonstrating its use with Bacillus subtilis.

The mutational landscape of Bacillus subtilis conditional hypermutators shows how proofreading skews DNA polymerase error rates

Statistical modeling of bacterial promoter sequences for regulatory motif discovery with the help of transcriptome data: application to Listeria monocytogenes

The paper develops a statistical model to identify regulatory motifs in bacterial promoters using transcriptome data, applied to Listeria monocytogenes to discover a novel motif related to ribosomal protein gene regulation.