ImmunologyComputers in Biology and MedicinePeer-reviewed
Dynamic Modeling of Antibody Repertoire Reshaping in Response to Viral Infections
Zhaobin Xu, Qingzhi Peng, Junxiao Xu…·Qiangcheng Zeng
This study uses mathematical modeling to show that viral infections reshape the antibody repertoire through the proliferation of high-affinity antibody pools and contraction of low-affinity pools, with self-antigens maintaining antibody persistence.