Guiding biomolecular interactions in cells using de novo protein-protein interfaces
Abigail J. Smith, Franziska Thomas, Deborah K. Shoemark, Derek N. Woolfson, Nigel J. Savery
This paper designs de novo protein-protein interfaces to control biomolecular interactions in E. coli, demonstrating their ability to guide engineered protein-DNA interactions and modulate gene expression.
ACS Synthetic Biology · May 6, 2019Peer-reviewedSynthetic Biology