BiophysicsbioRxivPreprint
Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales
Kashish Jain, Dhruv Thakar, Kshitiz Parihar…·Shalini T. Low-Nam
This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.
DOI 10.64898/2026.10.06.757133