Kashish Jain

Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales

This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.

Elimination of senescent cells by mechanical cell competition

This study shows that progerin-induced senescent cells are eliminated by normal cells through mechanical competition and JNK/p38-MAPK pathways, while p16-induced senescent cells resist elimination.

Nano-clusters of ligand-activated integrins organize immobile, signalling active, nano-clusters of phosphorylated FAK required for mechanosignalling in focal adhesions

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin

This paper introduces a single-construct optogenetic tool to control talin dimerization, enabling precise manipulation of mechanotransduction in integrin-based adhesions.