Author

Kshitiz Parihar

University of PennsylvaniaORCID 0000-0002-1072-1798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ravi RadhakrishnaniD· 3 shared Anne Herrmann· 1 shared Anne van Oosten· 1 shared Arnab MaitiiD· 1 shared Bidisha SinhaiD· 1 shared Daniel V. IwamotoiD· 1 shared Dhiraj Devidas BhatiaiD· 1 shared Dhruv ThakariD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Ravi RadhakrishnanORCID

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3 papers

Recent·Most cited

Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales

Kashish Jain, Dhruv Thakar, Kshitiz Parihar, Jenny JY Lin, Mary-Kate Hayward, Moses Musiime, Jonathan N. Lakins, Scott D. Hansen, Ravi Radhakrishnan, Jay T. Groves, Valerie Marie Weaver, Shalini T. Low-Nam

This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.

bioRxiv · Oct 9, 2026 · PreprintBiophysics

Enzyme-Regulated Non-Thermal Fluctuations Enhance Ligand Diffusion and Receptor-Mediated Endocytosis

Nividha, Arnab Maiti, Kshitiz Parihar, Rik Chakraborty, Pratibha Agarwala, Dibyendu Kumar Sasmal, Ravi Radhakrishnan, Tanmoy Ghosh, Bidisha Sinha, Dhiraj Devidas Bhatia, Krishna Kanti Dey

This study shows enzyme activity enhances ligand diffusion and receptor-mediated endocytosis by generating mechanical fluctuations in the extracellular matrix.

Small · Jun 11, 2026Peer-reviewedBiophysics

Tissue-dependent mechanosensing by cells derived from human tumors

Kshitiz Parihar, Jonathan Nukpezah, Daniel V. Iwamoto, Katrina Cruz, Fitzroy J. Byfield, LiKang Chin, Maria E. Murray, Melissa G. Mendez, Anne van Oosten, Anne Herrmann, Elisabeth E. Charrier, Peter A. Galie, Megan Donlick, Tongkeun Lee, Paul A. Janmey, Ravi Radhakrishnan

The paper investigates how cells from different tissue types respond to changes in ECM mechanics and composition, finding significant heterogeneity and the role of HA in modulating cell mechanics.

npj Biological Physics and Mechanics. · Aug 6, 2025Peer-reviewedBiophysics