Author

Mary-Kate Hayward

University of California, San FranciscoORCID 0000-0001-7482-5046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Valerie Marie WeaveriD· 2 shared Andrei GogaiD· 1 shared Andrew R. Beardsley· 1 shared Daniel Van de Mark· 1 shared Dhruv ThakariD· 1 shared Hani GoodarziiD· 1 shared Harrison WismeriD· 1 shared Jay T. GrovesiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Valerie Marie WeaverORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 9, 2026

Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales

Kashish Jain, Dhruv Thakar, Kshitiz Parihar…·Shalini T. Low-Nam

This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.

DOI 10.64898/2026.10.06.757133

statistical model

Cancer BiologybioRxivPreprintSep 26, 2024

Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

Rachel M. Nakagawa, Andrew R. Beardsley, Sophia Durney…·Andrei Goga

This study shows that YAP activation in monolayer cultures causes resistance to EGFR/KRAS/BRAF pathway inhibitors, while spheroids are more sensitive, highlighting differences in culture systems for modeling cancer progression.

DOI 10.1101/2024.09.26.615226

humanbulk RNA-seq