Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales
Kashish Jain, Dhruv Thakar, Kshitiz Parihar, Jenny JY Lin, Mary-Kate Hayward, Moses Musiime, Jonathan N. Lakins, Scott D. Hansen, Ravi Radhakrishnan, Jay T. Groves, Valerie Marie Weaver, Shalini T. Low-Nam
This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.
bioRxiv · Oct 9, 2026 · PreprintBiophysics