Kaempferol exerts anti-inflammatory effects by accelerating Treg development via AhR-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/RALDH2 gene in dendritic cells
Miki Takahashi, Kazuki Nagata, Yumi Watanuki, Masaki Yamaguchi, Kenta Ishii, Tomohiro Harada, Natsuki Minamikawa, Mayuka Katagiri, Weiting Zhao, Naoto Ito, Takuya Yashiro, Chiharu Nishiyama
This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.
Allergy · Dec 11, 2024Peer-reviewedImmunology