BioinformaticsBioinformaticsPeer-reviewed
TopicNet: a framework for measuring transcriptional regulatory network change
Shaoke Lou, Tianxiao Li, Xiangmeng Kong…·Mark Gerstein
TopicNet measures transcriptional regulatory network change by abstracting gene regulatory topics and quantifying rewiring scores between cellular states, revealing TFs with significant network connectivity changes and their impact on cancer survival.
44 citations