ImmunologybioRxivPreprint
ALOX12B overexpression in the skin drives inflammasome/Th17 signaling axis to promote inflammation in the mouse model and human patients
Suman Singh, Farhan Ahmed, Naireen Fatima…·Nooruddin Khan
This study identifies ALOX12B as a driver of skin inflammation through the inflammasome/Th17 signaling axis, showing its overexpression in psoriasis and atopic dermatitis and demonstrating a novel inhibitor's efficacy in a mouse model.
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