Cell BiologybioRxivPreprint
Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder
Conroy O. Field, Amrita Sarkar, Khalil H. Bdeir…·Mortimer Poncz
This study identifies PF4 as a central factor in APS by showing it bridges {beta}2GPI to NETs, forming prothrombotic complexes that are targeted by APS antibodies.
2 citations