Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder
Conroy O. Field, Amrita Sarkar, Khalil H. Bdeir, Hyun‐Jun Kim, Santosh K. Yadav, Jenna Oberg, Guohua Zhou, Steven Jiang, Manas Gumedeli, Keith R. McCrae, Gowthami M. Arepally, Jérôme Rollin, Yves Gruel, Thomas L. Ortel, Maria Anna Kowalska, , Mortimer Poncz
This study identifies PF4 as a central factor in APS by showing it bridges {beta}2GPI to NETs, forming prothrombotic complexes that are targeted by APS antibodies.
bioRxiv · Nov 7, 2025 · PreprintCell Biology