Weijun Chen

This study characterizes intra-host SARS-CoV-2 genomic variants and their evolutionary dynamics in COVID-19 patients using deep sequencing data.

This study compares SARS-CoV-2 viral populations in COVID-19 patients to show narrow transmission bottlenecks and stochastic dynamics in intra-host and inter-host evolution.

The paper identifies CTP synthesis as a metabolic bottleneck that constrains SARS-CoV-2 evolution towards attenuation and highlights viperin's role in antiviral defense.

This paper compares amplicon, hybrid capture, and metatranscriptomic sequencing methods for directly sequencing SARS-CoV-2 genomes from clinical samples, finding differences in bias, sensitivity, and accuracy.

This study evaluates metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid for diagnosing central nervous system infections, finding it detects pathogens in 36.6% of cases with some false positives and negatives.