Antoine Danchin

This study shows that the bacterial-derived compound STL-101 (queuine) protects neurons in vitro by reducing alpha-synuclein and tau hyperphosphorylation in neurodegenerative models.

The paper identifies CTP synthesis as a metabolic bottleneck that constrains SARS-CoV-2 evolution towards attenuation and highlights viperin's role in antiviral defense.

The paper develops interpretable metagenomics prediction models based on microbial taxon abundance ratios, additions, and subtractions, achieving performance comparable to or better than traditional machine learning methods.

The paper estimates the probability of CRISPR-based gene drive contamination in non-target species using a quantitative model and discusses strategies to reduce this risk.