Author

Avijit Mainan

Indian Institute of Science Education and Research KolkataORCID 0000-0002-1264-3674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:structural biology· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Susmita RoyiD· 3 shared Akhilesh JaiswariD· 2 shared José N. OnuchiciD· 1 shared Karissa Y. SanbonmatsuiD· 1 shared Raju Sarkar· 1 shared Rimi Kundu· 1 shared Serdal KırmızıaltıniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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3 shared papersBiophysics

Susmita RoyORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 1, 2026

Structural Topology-based Electrostatic Model (STEM) Reveals Ion-Coordination Exchange as a Driver of RNA Folding Dynamics

Avijit Mainan, Akhilesh Jaiswar, José N. Onuchic…·Susmita Roy

The paper introduces STEM, a model that captures ion-coordination dynamics in RNA folding, showing how Mg2+ coordination drives conformational transitions and folding pathways.

1 citation

structural biologydeep learning

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BiophysicsbioRxivPreprintMay 4, 2026

Connecting Cryo-EM and Crystallographic Views of RNA Folding through Ionic Conditions and Structural Flexibility

Avijit Mainan, Serdal Kırmızıaltın, Susmita Roy

This study investigates how ionic conditions and structural flexibility affect RNA folding by comparing cryo-EM and XRD structures of the SARS-CoV-2 frameshifting stimulatory element.

DOI 10.64898/2026.05.02.722415

cryo-EMstructural biology

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BiophysicsbioRxivPreprintMay 20, 2025

Free Energy Landscape of Magnesium Chelation Reveals Dynamic Pre-Chelate Complexes Stabilized by Meta-Sphere RNA-Ion Coordination

Akhilesh Jaiswar, Raju Sarkar, Avijit Mainan…·Susmita Roy

The paper uses simulations to analyze Mg2+ coordination with RNA, identifying dynamic pre-chelate complexes and a new meta-sphere coordination mechanism.

1 citation

structural biologystatistical model

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