Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype
Sanne Reijm, Ana M. Marques, Jasper Rip, Cato E. A. Corsten, Annet F. Wierenga‐Wolf, Harm de Wit, Marie‐José Melief, Yifan van Hasselt, Jamie van Langelaar, Rinze Frederik Neuteboom, Beatrijs H. A. Wokke, Yvonne M. Mueller, Joost Smolders, Marvin M. van Luijn
The paper examines how HLA-B7 and HLA-A2 alleles influence EBV-specific CD8+ T cell effector phenotypes and their association with MS, finding HLA-B7-restricted cells are more exhausted and CNS-resident in MS patients.
iScience · Apr 15, 2026Peer-reviewedImmunology