Joost Smolders

The paper examines how HLA-B7 and HLA-A2 alleles influence EBV-specific CD8+ T cell effector phenotypes and their association with MS, finding HLA-B7-restricted cells are more exhausted and CNS-resident in MS patients.

The paper identifies an 11-fold increase in CD4+ T-cells in the hypocretin region of NT1 brains, correlating with symptom severity.

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.