ImmunologyiSciencePeer-reviewed
Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype
Sanne Reijm, Ana M. Marques, Jasper Rip…·Marvin M. van Luijn
The paper examines how HLA-B7 and HLA-A2 alleles influence EBV-specific CD8+ T cell effector phenotypes and their association with MS, finding HLA-B7-restricted cells are more exhausted and CNS-resident in MS patients.
DOI 10.1016/j.isci.2026.115744