Pierre L. Hainaut

The paper analyzes how neoantigenic properties of TP53 variants correlate with cancer risk and presentation in Li-Fraumeni syndrome carriers.

The paper develops TLSCP, a transfer learning method for survival-based clustering of predictors, applied to TP53 mutation annotation, showing improved clustering and clinical interpretability.

This paper shows that LKB1 is essential for ENS development by reducing oxidative stress and p53 activity, leading to hypoganglionosis and digestive issues when LKB1 is lost.