Alexeï Grichine

Hck signaling drives long-distance ECM degradation through endo-exocytosis coupling in macrophages.

This study identifies HCK signaling as a driver of long-distance ECM degradation in macrophages through endo-exocytosis coupling involving MMPs and cathepsins.

Winding-Up of Fibrin Fibers as a Novel Mechanism of Platelet-Mediated Fiber Compaction

This study identifies a novel platelet mechanism for fibrin fiber compaction through actomyosin-driven wrapping and bulb formation during clot retraction.

Optogenetic SH3 nanoclustering of SRC and HCK uncovers the functional specificity of these redundant kinases in macrophages.

This study uses optogenetic tools to reveal distinct functional roles of SRC and HCK kinases in macrophages, despite their redundancy.

The metabolic kinase LKB1 shapes the enteric nervous system bymitigating the oxidative stress and p53 activity

This paper shows that LKB1 is essential for ENS development by reducing oxidative stress and p53 activity, leading to hypoganglionosis and digestive issues when LKB1 is lost.