Zhonghui Guan

This study shows that microglia accumulate lipid droplets after neonatal brain hypoxia-ischemia, leading to a pro-inflammatory state and increased phagocytosis.

This study uses single-nuclear RNA sequencing to show that ATF3 is not required for postoperative pain, and identifies c-Jun as a potential ATF3-independent driver of the injury program.

This study identifies orexinergic projections to the substantia innominata as critical for arousal and analgesia, showing their modulation by anesthesia and OX2R-mediated effects.