Willard N. Applefeld

This paper investigates how myocyte damage and mass loss in septic cardiomyopathy affect left ventricular compliance, water content, and survival outcomes.

This study shows that cardiac dysfunction in septic shock occurs without high catecholamine levels or microvascular ischemia, and epinephrine infusions cause prolonged microvascular perfusion issues.

This study uses cardiac magnetic resonance imaging in a canine sepsis model to show that ventricular wall edema and structural changes, not preload or afterload, explain differences in cardiac function and survival outcomes during sepsis.