BiochemistryACS Chemical BiologyPeer-reviewed
Repurposing of the RIPK1 selective benzooxazepin-4-one scaffold for the development of a type-III LIMK1/2 inhibitor
Sebastian Mandel, Thomas Hanke, Sebastian Mathea…·Stefan Knapp
The paper repurposes a benzoxazepinone scaffold originally designed for RIPK1 inhibition to develop a novel type-III LIMK1/2 inhibitor with high selectivity.