Author

Haibo Xie

Ocean University of ChinaORCID 0000-0002-1350-9557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:zebrafish· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Chengtian ZhaoiD· 2 shared Anas M. Khanshour· 1 shared Carol A. WiseiD· 1 shared Changxin Wu· 1 shared Chikashi C. TeraoiD· 1 shared DISCO study group (Deciphering Disorders Involving Scoliosis & COmorbidities)· 1 shared G. Chen· 1 shared Guixing QiuiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Chengtian ZhaoORCID

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3 papers

Recent·Most cited

Hedgehog Pathway Activity Downstream of Smoothened is regulated specifically by Basal Ciliary PKA

Hongyu Zhang, Shujing Chen, Zhuoya Huang, Jin Ben, Yanling Wei, G. Chen, Changxin Wu, Haibo Xie, Philip William Ingham, Zhonghua Zhao

This study investigates how PKA activity in primary cilia regulates the Hedgehog pathway, showing that ciliary PKA specifically modulates the pathway even when cilia are disrupted.

Cellular & Molecular Biology Letters · Apr 9, 2026Peer-reviewedCell Biology

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

Lianlei Wang, Xinyu Yang, Sen Zhao, Pengfei Zheng, Wen Wen, Kexin Xu, Xi Cheng, Qing Li, Anas M. Khanshour, Yoshinao Koike, Junjun Liu, Xin Fan, Nao Otomo, Zefu Chen, Yaqi Li, , Nan Wu

This study identifies EPHA4 signaling dysregulation as a contributor to idiopathic scoliosis by linking it to locomotion defects and CPG network disruption in zebrafish.

eLife · Jul 15, 2025Peer-reviewedGenetics

Cilia regulate meiotic recombination in zebrafish

Haibo Xie, Xiaosi Wang, Minjun Jin, Lanqin Li, Junwen Zhu, Yunsi Kang, Zhe Chen, Yonghua Sun, Chengtian Zhao

This study shows that cilia regulate meiotic recombination in zebrafish by affecting double strand break repair, crossover formation, and germ cell survival.

Journal of Molecular Cell Biology · Jul 1, 2022Peer-reviewedDevelopmental Biology